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How Cancer Evolution Limits Precision Cancer Medicine

Story Highlights
  • Cancer progression can be thought as a within-patient evolution.
  • Interaction between stochastic, where different outcomes arise (even if initial state is identical), and deterministic, where the outcomes are determined by the initial state, limits cancer predictability.
  • Fitness landscapes, which are simplified graphic representation of fitness as a function of genotype, can be used to predict cancer development.
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