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Firstly in a normal chromosome happened a mutation of the TP53 gene (1)
After the mutation of the gene , the chromosomr goes into a catastrophic fragmantation/breakage into many peaces(2)
The imperfect reassemby of the many peaces (3) can lead to the formation of a cancer cell, that develope into tumor(4)
Adapt from 2012 Elsevier Inc