Insecticides have been used to kill pests and bugs as well as acting as a disinfectant to kill any type of bacteria. Ingestion of food that has been sprayed with insecticide would cause small levels of it to be found throughout the diet. Up until now, little was known about the effects of ingesting insecticides, and what health risks they offer. Researchers have discovered that a risk of type II diabetes can be traced from ingestion of the poison.

When ingesting Insecticide, researchers had discovered a correlation between the product and disruptions in the circadian sleep rhythm. Connections with circadian activity and metabolic process are unknown, but there is a higher incidence of diabetes and other forms of metabolic diseases. The correlation was found when researchers tested two forms of insecticides, carbaryl and carbofuran, both of which are extremely toxic chemicals which have been banned in several countries.

Melatonin is the regulator of our natural clock, which works to keep several functions working. One of which is its important regulations on the pancreas. Due to upkeep in the amount of insulin released during the day and night, those with disrupted melatonin release have been known to incur symptoms of type II Diabetes. Melatonin has a structure that is likecarbaryl and carbofuran, the two chemicals tested, and have similar properties as well.

Researchers believe this occurs due to an affinity for MT2 receptors which potentially affect glucose homeostasis. Thus, this puts people at risk for disrupted sleeping patterns as well as diabetes. This hypothesis, tested by in vivo and in vitro techniques, looked for various diseases caused by introducing the chemical. Similar tests were also done by clustering chemicals which cause diabetes and found that they all contain similar structures or functional groups to melatonin.

Preliminary findings have identified this potential link between insecticides and the effects on the circadian system, although this has been the first time this has been tested and found to be true. Extensive and continual research should continue to learn and understand the mechanism that occurs.


COPYRIGHT: This article is property of We Speak Science, a non profit institution co-fonded by Dr. Detina Zalli (Harvard University) and Dr. Argita Zalli (Imperial College London). The article is written by Argita Zalli and Antonio Del Vecchio (Cornell University).